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鍏充簬鑲ュ帤鍨嬪績鑲岀梾<\/u><\/b><\/p> \n

鑲ュ帤鍨嬪績鑲岀梾涓昏鏄敱浜庣紪鐮佽倢灏忚妭鐩稿叧铔嬬櫧鍩哄洜鑷寸梾鎬у彉寮傚鑷寸殑锛屾垨鐥呭洜涓嶆槑鐨勪互蹇冭倢鑲ュ帤涓虹壒寰佺殑蹇冭倢鐥咃紝宸﹀績瀹ゅ鍙楃疮甯歌锛岄渶鎺掗櫎鍏朵粬鐨勫績琛€绠$柧鐥呮垨鍏ㄨ韩鎬с€佷唬璋㈡€х柧鐥呭紩璧风殑蹇冨澹佸鍘氥€傛嵁浼扮畻锛屾垜鍥界粡骞撮緞鍜屾€у埆鏍℃鍚庣殑鎮g梾鐜囩害涓�80\/10涓�5<\/sup>銆傝偉鍘氬瀷蹇冭倢鐥呬笌鎴块ⅳ銆佸崚涓€佸績鍔涜“绔拰蹇冭剰鎬х対姝婚闄╃殑澧炲姞鏈夊叧銆�<\/p> \n

HCM鏍规嵁鏄惁瀛樺湪宸﹀績瀹ゆ祦鍑洪亾锛圠VOT锛夋闃诲彲鍒嗕负姊楅樆鎬у拰闈炴闃绘€с€傚湪姊楅樆鎬ф垨闈炴闃绘€CM鎮h€呬腑锛屼綋鍔涙椿鍔ㄥ彲瀵艰嚧鐤插姵鎴栧懠鍚稿洶闅撅紝涓ラ噸褰卞搷鎮h€呯殑鏃ュ父宸ヤ綔鍜岀敓娲汇€�<\/p> \n

鍏充簬杩堝嚒濡�<\/u><\/b>®<\/sup><\/u><\/b>锛堢帥浼愬嚡娉拌兌鍥婏級<\/u><\/b><\/p> \n

杩堝嚒濡�®<\/sup>锛堢帥浼愬嚡娉拌兌鍥婏級鏄涓笖涓浗鐩墠鍞竴鑾峰緱鎵瑰噯鐨勫績鑲岃倢鐞冭泲鐧芥姂鍒跺墏锛岀敤浜庢不鐤楃航绾﹀績鑴忓崗浼氾紙NYHA锛夊績鍔熻兘鍒嗙骇II-III绾х殑姊楅樆鎬ц偉鍘氬瀷蹇冭倢鐥咃紙oHCM锛夋垚浜烘偅鑰咃紝浠ユ敼鍠勮繍鍔ㄨ兘鍔涘拰鐥囩姸銆傝繄鍑″Ε®<\/sup>鍦ㄦ鐩熻幏鎵圭敤浜庢不鐤楁湁鐥囩姸锛圢YHA蹇冨姛鑳藉垎绾I-III绾э級鐨勬闃绘€ц偉鍘氬瀷蹇冭倢鐥呮垚浜烘偅鑰呫€傝鑽篃宸插湪浜斿ぇ娲茬殑鍏朵粬澶氫釜鍥藉鍜屽湴鍖鸿幏鎵逛笂甯傦紝鍖呮嫭缇庡浗銆侀樋鏍瑰环銆佹境澶у埄浜氥€佸反瑗裤€佸姞鎷垮ぇ銆佹櫤鍒┿€佽嫳鍥姐€佷腑鍥介娓€佷互鑹插垪銆佷腑鍥芥境闂ㄣ€佹柊鍔犲潯銆侀煩鍥姐€佺憺澹拰闃胯仈閰嬬瓑銆傝繄鍑″Ε®<\/sup>鏄竴绉嶅績鑲岃倢鐞冭泲鐧介€夋嫨鎬х殑鍙樻瀯銆佸彲閫嗘€ф姂鍒跺墏锛屽叾閫氳繃璋冭妭鑳借繘鍏�"鍙粨鍚堣倢鍔ㄨ泲鐧�"锛堜骇鐢熸敹缂╁姏锛夌姸鎬佺殑鑲岀悆铔嬬櫧澶寸殑鏁伴噺锛屼粠鑰屽噺灏戝姩鍔涗骇鐢燂紙鏀剁缉鏈燂級鍜屾畫鐣欙紙鑸掑紶鏈燂級妯ˉ褰㈡垚鐨勬鐜囥€侶CM鐨勪富瑕佺梾鐞嗙敓鐞嗘満鍒剁壒寰佸湪浜庤繃閲忚倢鐞冭泲鐧�-鑲屽姩铔嬬櫧妯ˉ鐨勫舰鎴愬拰瓒呮澗寮涚姸鎬佺殑澶辫皟锛岃繄鍑″Ε®<\/sup>鑳藉灏嗘暣浣撹倢鐞冭泲鐧界兢鏈夋晥杞彉鑷宠妭鑳戒笖鍙嫙闆嗙殑瓒呮澗寮涚姸鎬併€傚浜嶩CM鎮h€咃紝杩堝嚒濡�®<\/sup>鎶戝埗蹇冭倢鑲岀悆铔嬬櫧锛屼粠鑰屽噺杞诲姩鎬佸乏蹇冨娴佸嚭閬擄紙LVOT锛夋闃诲苟鏀瑰杽蹇冭剰鍏呯泩鍘嬨€�<\/p> \n

鍏充簬<\/u><\/b>EXPLORER-CN<\/u><\/b><\/p> \n

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璇ョ爺绌朵富瑕佺枟鏁堢粓鐐规槸浠庡熀绾垮埌绗�30鍛╒alsalva LVOT宄板€煎帇宸殑鍙樺寲銆傛洿澶氬叧浜� EXPLORER-CN 璇曢獙鐨勪俊鎭紝鍙櫥褰旵linicalTrials.gov (NCT05174416)鎴� http:\/\/www.chinadrugtrials.org.cn\/index.html<\/a> (CTR20212890)杩涜鏌ヨ銆�<\/p> \n

鍏充簬<\/u><\/b>EXPLORER-HCM鍜孧AVA-LTE涓村簥璇曢獙<\/u><\/b><\/p> \n

EXPLORER-HCM鐮旂┒鏄竴椤瑰弻鐩层€侀殢鏈恒€佸畨鎱板墏瀵圭収銆佸钩琛屽垎缁処II鏈熶复搴婅瘯楠岋紙NCT03470545锛夛紝绾冲叆浜�251鍚嶆湁鐥囩姸锛圢YHA蹇冨姛鑳藉垎绾I 绾ф垨III 绾э級鐨勬闃绘€ц偉鍘氬瀷蹇冭倢鐥�(oHCM)鎴愪汉鎮h€呫€傛墍鏈夋偅鑰呯殑宸﹀績瀹ゅ皠琛€鍒嗘暟锛圠VEF锛夊潎鍙祴瀹氫笖鈮�55%锛屼笖鑷冲皯鏈変竴涓狶VOT宄板€煎帇宸� 鈮�50 mmHg锛堥潤鎭椂鎴栨縺鍙戝悗锛夈€傛澶栵紝绛涢€夋椂鎮h€呭熀绾縑alsalva LVOT鍘嬪樊搴斺墺30 mmHg銆�92%鐨勬偅鑰呮帴鍙椾簡鑳屾櫙娌荤枟锛屽寘鎷插彈浣撻樆婊炲墏鍗曡嵂娌荤枟鎴栭挋閫氶亾闃绘粸鍓傚崟鑽不鐤椼€備富瑕佺粓鐐规槸绗�30鍛ㄦ椂璇勪及鐨勫鍚堝姛鑳界粓鐐癸紝瀹氫箟涓哄嘲鍊艰€楁哀閲忥紙pVO2<\/sub>锛夋敼鍠勨墺1.5 mL\/kg\/min涓擭YHA蹇冨姛鑳藉垎绾ф敼鍠勮嚦灏�1绾ф垨pVO2<\/sub>鏀瑰杽鈮�3.0 mL\/kg\/min涓擭YHA蹇冨姛鑳藉垎绾ф湭鎭跺寲鐨勬偅鑰呮瘮渚嬨€傚叧閿瑕佺粓鐐瑰寘鎷熀绾胯嚦绗�30鍛ㄨ繍鍔ㄥ悗LVOT鍘嬪樊銆乸VO2<\/sub>銆丯YHA蹇冨姛鑳藉垎绾с€佸牚钀ㄦ柉鍩庡績鑲岀梾璋冩煡闂嵎锛圞CCQ锛夊拰鑲ュ帤鍨嬪績鑲岀梾鐥囩姸闂嵎锛圚CMSQ锛夌殑缁撴灉鍙樺寲銆�<\/p> \n

EXPLORER-LTE鏄疢AVA-LTE鐮旂┒锛圢CT03723655锛夌殑鍏朵腑涓€涓槦鍒楋紝鏄竴椤规鍦ㄨ繘琛岀殑鍓傞噺璁剧洸鐨勭帥浼愬嚡娉颁簲骞存湡鐮旂┒锛岀爺绌朵汉缇ゆ槸瀹屾垚EXPLORER-HCM涓村簥璇曢獙鐨勬湁鐥囩姸鐨勬闃绘€ц偉鍘氬瀷蹇冭倢鐥呮偅鑰呫€侲XPLORER-LTE闃熷垪鐨勬墍鏈夋偅鑰呰捣濮嬫帴鍙楁瘡澶�5 mg鐜涗紣鍑嘲娌荤枟锛屽苟鍦ㄧ4銆�8鍜�12鍛ㄨ繘琛岃秴澹板績鍔ㄥ浘妫€鏌ワ紝鏍规嵁鐮旂┒涓績璇诲彇鐨刅alsalva LVOT鍘嬪樊鍜孡VEF娴嬮噺鍊艰繘琛屽墏閲忚皟鏁淬€傚湪绗�24鍛ㄦ椂鏍规嵁鐮旂┒涓績璇诲彇鐨勮繍鍔ㄥ悗LVOT鍘嬪樊锛屼篃鍙繘琛屽墏閲忚皟鏁淬€傜24鍛ㄤ箣鍚庯紝濡傛灉鐮旂┒涓績璇诲彇鐨刅alsalva LVOT鍘嬪樊 >30 mmHg涓擫VEF鈮�50%锛屽彲杩涜鍓傞噺璋冩暣銆�<\/p> \n

\n \n \n \n \n \n \n

[1]<\/sup><\/span> 鍥藉蹇冭绠$梾涓績蹇冭倢鐥呬笓绉戣仈鐩�, 绛�. 涓浗寰幆鏉傚織,2023,38(1):1-33.<\/span><\/p> <\/td> \n <\/tr> \n

[2]<\/sup><\/span> Ommen SR, et al; American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(23).<\/span><\/p> <\/td> \n <\/tr> \n

[3] <\/sup><\/span>Arbelo E, et al; ESC Scientific Document Group. Eur Heart J. 2023 Oct 1;44(37):3503-3626.<\/span><\/p> <\/td> \n <\/tr> \n

[4]<\/sup><\/span> 鍥藉蹇冭绠$梾涓撳濮斿憳浼氬績鍔涜“绔笓涓氬鍛樹細, 涓浗鍖诲笀鍗忎細蹇冨姏琛扮涓撲笟濮斿憳浼�, 涓崕鍖诲浼氬績琛€绠″垎浼氬績鍔涜“绔缁�, 绛�. 涓浗鑲ュ帤鍨嬪績鑲岀梾鎸囧崡 2022[J]. 涓崕蹇冨姏琛扮鍜屽績鑲岀梾鏉傚織, 2022, 6(2): 80-105. DOI: 10.3760\/cma.j.cn1101460-20220805-00070.<\/span><\/p> <\/td> \n <\/tr> \n <\/tbody> \n <\/table> \n<\/div> \n

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