鍏充簬<\/b>DESTINY-Lung05<\/b><\/p> \n

DESTINY-Lung05鏄竴椤瑰湪涓浗杩涜鐨勫紑鏀炬爣绛俱€佸崟鑷傗叀鏈熶复搴婅瘯楠岋紝鐢ㄤ簬璇勪及寰锋洸濡ョ彔鍗曟姉锛�5.4 mg\/kg锛夊湪鏃㈠線鑷冲皯鎺ュ彈涓€绾胯嵂鐗╂不鐤楁垨娌荤枟涔嬪悗鐤剧梾杩涘睍鐨凥ER2绐佸彉NSCLC鎮ｈ€呬腑鐨勫畨鍏ㄦ€у拰鏈夋晥鎬с€�<\/p> \n

璇ヨ瘯楠岀殑涓昏缁堢偣鏄粡ICR璇勪及鐨勫瑙傜紦瑙ｇ巼锛圤RR锛夈€傛瑕佺粓鐐瑰寘鎷爺绌惰€呰瘎浼扮殑cORR銆両CR鍜岀爺绌惰€呰瘎浼扮殑缂撹В鎸佺画鏃堕棿锛圖oR锛夈€佺柧鐥呮帶鍒剁巼锛圖CR锛夈€佹棤杩涘睍鐢熷瓨鏈燂紙PFS锛夊拰瀹夊叏鎬с€侱ESTINY-Lung05鍦ㄤ腑鍥界殑澶氫釜鍦扮偣鎷涘嫙浜�72鍚嶆偅鑰呫€傛湁鍏宠瘯楠岀殑鏇村淇℃伅锛岃璁块棶clinicaltrials.gov<\/a>銆�<\/p> \n

鍏充簬<\/b>DESTINY-Lung02<\/b><\/p> \n

DESTINY-Lung02鏄竴椤瑰叏鐞冦€侀殢鏈衡叀鏈熶复搴婅瘯楠岋紝璇勪及寰锋洸濡ョ彔鍗曟姉鍦℉ER2绐佸彉鐨勪笉鍙垏闄ゅ拰\/鎴栬浆绉绘€ч潪灏忕粏鑳炶偤鐧屾偅鑰呯殑瀹夊叏鎬у拰鐤楁晥锛岃繖浜涙偅鑰呭湪鎺ュ彈鑷冲皯涓€绉嶆姉鐧屾不鐤楁柟妗堬紙蹇呴』鍖呭惈閾傜被鍖栫枟锛夋湡闂存垨涔嬪悗鍙戠敓鐤剧梾澶嶅彂鎴栬繘灞曘€傛偅鑰呮寜2:1闅忔満鎺ュ彈寰锋洸濡ョ彔鍗曟姉5.4mg\/kg(n=102)鎴�6.4mg\/kg(n=50)銆�<\/p> \n

璇ヨ瘯楠岀殑涓昏缁堢偣鏄粡鐩叉硶鐙珛涓績瀹℃煡锛圔ICR锛夎瘎浼扮殑纭瀹㈣缂撹В鐜囷紙ORR锛夈€傛瑕佺粓鐐瑰寘鎷敱鐮旂┒鑰呭拰BICR璇勪及鐨凞CR銆丏oR鍜孭FS浠ュ強OS鍜屽畨鍏ㄦ€с€侱ESTINY-Lung02鍦ㄤ簹娲层€佹娲层€佸寳缇庡拰澶ф磱娲茬殑澶氫釜鍦扮偣鎷涘嫙浜�152鍚嶆偅鑰呫€傛湁鍏宠瘯楠岀殑鏇村淇℃伅锛岃璁块棶ClinicalTrials.gov<\/a>銆�<\/p> \n

鍏充簬<\/b>HER2<\/b>绐佸彉闈炲皬缁嗚優鑲虹檶<\/b><\/p> \n

鑲虹檶鏄叏鐞冩渶甯歌鐨勭檶鐥囷紝涔熸槸鐧岀棁鐩稿叧姝讳骸鐨勪富瑕佸師鍥�^{[6]<\/sup>銆�2022骞达紝鍏ㄧ悆绾︽湁250涓囨偅鑰呰璇婃柇涓鸿偤鐧岋紝鎶ュ憡浜嗙害180涓囦緥姝讳骸[6]<\/sup>銆傚浜庤浆绉绘€SCLC鎮ｈ€咃紝棰勫悗灏ゅ叾涓嶄匠锛屽彧鏈夊ぇ绾�9%鐨勬偅鑰呰兘鍦ㄨ瘖鏂悗鐢熷瓨瓒呰繃浜斿勾[11]<\/sup>銆�<\/p> \n}

鑲虹檶鐨勫彂鐥呯巼鍦ㄤ簹娲茬壒鍒槸鍦ㄤ腑鍥芥槑鏄炬洿楂橈紝瓒呰繃涓夊垎涔嬩竴鐨勫叏鐞冪梾渚嬪彂鐢熷湪涓浗^{[5]<\/sup>,[<\/sup>6]<\/sup>銆傝偤鐧屾槸涓浗鏈€甯歌鐨勭檶鐥囷紝2022骞存湁瓒呰繃100涓囩殑鏂板彂鐥呬緥[5]<\/sup>銆傛澶栵紝瀹冧篃鏄腑鍥界檶鐥囩浉鍏虫浜＄殑涓昏鍘熷洜锛�2022骞存姤鍛婁簡瓒呰繃73.3涓囦緥姝讳骸[5]<\/sup>銆傚湪涓浗锛屽ぇ绾�68%鐨勬偅鑰呭湪璇婃柇鏃跺凡澶勪簬鏅氭湡[12]<\/sup>銆�<\/p> \n}

HER2鏄竴绉嶉叒姘ㄩ吀婵€閰跺彈浣撶敓闀夸績杩涜泲鐧斤紝琛ㄨ揪鍦ㄥ绉嶈偪鐦ょ被鍨嬬殑琛ㄩ潰銆傛煇浜汬ER2锛圗RBB2锛夊熀鍥犳敼鍙橈紙绉颁负HER2绐佸彉锛夊凡鍦ㄩ潪槌炵姸NSCLC鎮ｈ€呬腑琚‘瀹氫负涓€绉嶇嫭鐗圭殑鍒嗗瓙闈舵爣锛屽苟涓斿彂鐢熷湪澶х害2%鑷�4%鐨勮繖绉嶇被鍨嬭偤鐧屾偅鑰呬腑^{[8]<\/sup>,[<\/sup>9]<\/sup>銆傝櫧鐒禜ER2绐佸彉鍙兘鍙戠敓鍦ㄥ悇绉嶆偅鑰呬腑锛屼絾瀹冧滑鏇村父瑙佷簬骞磋交銆佸コ鎬т笖浠庢湭鍚哥儫鐨凬SCLC鎮ｈ€�[13]<\/sup>銆侶ER2绐佸彉涓庣檶缁嗚優鐢熼暱鍜岄鍚庝笉鑹嫭绔嬬浉鍏筹紝涓斾笌鑴戣浆绉诲彂鐢熺巼澧炲姞鐩稿叧[14]<\/sup>銆侶ER2锛圗RBB2锛夌獊鍙樺凡鍙€氳繃涓嬩竴浠ｆ祴搴忔妧鏈繘琛岃瘑鍒�[15]<\/sup>銆�<\/p> \n}

鍏充簬娉ㄥ皠鐢ㄥ痉鏇插Ε鐝犲崟鎶�<\/b><\/p> \n

娉ㄥ皠鐢ㄥ痉鏇插Ε鐝犲崟鎶楋紙鍟嗗搧鍚嶏細浼樿但寰�^{®<\/sup>锛夋槸涓€娆綡ER2闈跺悜鎶椾綋鍋惰仈鑽墿锛圓DC锛夛紝閲囩敤绗竴涓夊叡涓撴湁鐨凞Xd-ADC鎶€鏈璁★紝鏄涓€涓夊叡鑲跨槫浜у搧缁勫悎涓殑棰嗗厛ADC锛屼篃鏄樋鏂埄搴稟DC绉戝骞冲彴涓渶鍏堣繘鐨勯」鐩€傚痉鏇插Ε鐝犲崟鎶楃敱浜烘簮鍖栨姉HER2鍗曞厠闅嗘姉浣撻€氳繃绋冲畾鐨勫彲瑁傝В鍥涜偨杩炴帴瀛愪笌鎷撴墤寮傛瀯閰�-I鎶戝埗鍓傦紙鍠滄爲纰辩被琛嶇敓鐗〥Xd锛夎繛鎺ョ粍鎴愩€�<\/p> \n}

鍩轰簬DESTINY-Breast03鐮旂┒鑾峰緱鐨勭粨鏋滐紝寰锋洸濡ョ彔鍗曟姉锛�5.4mg\/kg锛夊凡鍦ㄨ秴杩�65涓浗瀹禱/鍦板尯鑾峰緱鎵瑰噯銆�2023 骞� 2 鏈堬紝涓浗鍥藉鑽搧鐩戠潱绠＄悊灞€鎵瑰噯浼樿但寰�®鍗曡嵂鐢ㄤ簬娌荤枟鏃㈠線鎺ュ彈杩囦竴绉嶆垨涓€绉嶄互涓婃姉 HER2 鑽墿娌荤枟鐨勪笉鍙垏闄ゆ垨杞Щ鎬� HER2 闃虫€ф垚浜轰钩鑵虹檶鎮ｈ€呫€傜户2022骞村湥瀹変笢灏煎ゥ涔宠吅鐧岀爺璁ㄤ細锛�#SABCS锛変笂鍏竷寰锋洸濡ョ彔鍗曟姉娌荤枟HER2闃虫€ф櫄鏈熶钩鑵虹檶鎮ｈ€呯殑涓綅mPFS杈�28.8涓湀鍚庯紝2024骞�6鏈�2鏃�2024骞寸編鍥戒复搴婅偪鐦ゅ浼氾紙#ASCO24锛変腑鏇存柊浜嗗痉鏇插Ε鐝犲崟鎶楁不鐤桯ER2闃虫€ф櫄鏈熶钩鑵虹檶鎮ｈ€呯殑涓綅OS杈�52.6涓湀銆�<\/p> \n

鍩轰簬DESTINY-Breast04鐮旂┒鑾峰緱鐨勭粨鏋滐紝寰锋洸濡ョ彔鍗曟姉锛�5.4mg\/kg锛夊凡鍦�65澶氫釜鍥藉\/鍦板尯鑾峰緱鎵瑰噯銆傜敤浜庢不鐤楁棦寰€鍦ㄨ浆绉婚樁娈垫帴鍙楄繃鑷冲皯涓€绉嶇郴缁熸不鐤楃殑锛屾垨鍦ㄨ緟鍔╁寲鐤楁湡闂存垨瀹屾垚杈呭姪鍖栫枟涔嬪悗6涓湀鍐呭鍙戠殑锛屼笉鍙垏闄ゆ垨杞Щ鎬ER2浣庤〃杈撅紙IHC1+鎴朓HC2+\/鍘烮SH-锛夋垚浜轰钩鑵虹檶鎮ｈ€呫€�2023骞�7鏈堬紝璇ラ€傚簲鐥囪幏寰椾腑鍥藉浗瀹惰嵂鍝佺洃鐫ｇ鐞嗗眬锛圢MPA锛夋壒鍑嗕笂甯傘€�2022骞寸編鍥戒复搴婅偪鐦ゅ浼氾紙#ASCO22锛夊勾浼氫笂鍏竷鐨勬暟鎹樉绀猴紝寰锋洸濡ョ彔鍗曟姉娌荤枟HR闃虫€ER2浣庤〃杈捐浆绉绘€т钩鑵虹檶鎮ｈ€呯殑涓綅PFS 涓�10.1涓湀锛屼腑浣峅S涓�23.9涓湀銆�<\/p> \n

鍩轰簬DESTINY-Lung02\/ DESTINY-Lung05鐮旂┒鑾峰緱鐨勭粨鏋滐紝寰锋洸濡ョ彔鍗曟姉锛�5.4mg\/kg锛夊凡鍦ㄨ秴杩�45涓浗瀹惰幏寰楁壒鍑嗭紝鍗曡嵂閫傜敤浜庢不鐤椾娇鐢ㄧ粡褰撳湴鎴栧湴鍖烘壒鍑嗙殑妫€娴嬫柟娉曟娴嬪埌瀛樺湪HER2锛圗RBB2锛夋縺娲荤獊鍙樹笖鏃㈠線鎺ュ彈杩囧叏韬不鐤楃殑涓嶅彲鍒囬櫎鎴栬浆绉绘€ф垚浜洪潪灏忕粏鑳炶偤鐧岋紙NSCLC锛夋偅鑰呫€傝閫傚簲鐥囧湪涓浗鍜岀編鍥界殑鍚庣画鎵瑰噯鍙栧喅浜庣‘璇侀獙璇佹€х爺绌朵腑瀵逛复搴婅幏鐩婄殑楠岃瘉鍜屾弿杩般€�<\/p> \n

鍩轰簬DESTINY-Gastric01鍜孿/鎴朌ESTINY-Gastric02鍜孿/鎴朌ESTINY-Gastric06鐮旂┒鑾峰緱鐨勭粨鏋滐紝寰锋洸濡ョ彔鍗曟姉锛�6.4mg\/kg锛夊凡鍦ㄨ秴杩�45涓浗瀹禱/鍦板尯鑾锋壒鐢ㄤ簬娌荤枟鏃㈠線鎺ュ彈杩囨洸濡ョ彔鍗曟姉鐨勬不鐤楁柟妗堢殑灞€閮ㄦ櫄鏈熸垨杞Щ鎬ER2闃虫€ц儍鎴栬儍椋熺浜ょ晫澶勶紙GEJ锛夎吅鐧屾垚浜烘偅鑰呫€�2020骞�12鏈堬紝琚獵DE鎺堜簣绐佺牬鎬х枟娉曡瀹氥€�2024骞�8鏈�5鏃ワ紝璇ラ€傚簲鐥囪幏寰椾腑鍥藉浗瀹惰嵂鍝佺洃鐫ｇ鐞嗗眬锛圢MPA锛夋壒鍑嗕笂甯傘€傝閫傚簲鐥囧湪涓浗鑳藉惁瀹屽叏鎵瑰噯锛屽皢鍙栧喅浜庢鍦ㄨ繘琛岀殑闅忔満瀵圭収纭瘉涓村簥璇曢獙鑳藉惁璇佹槑璇ヤ汉缇ょ殑涓村簥鑾风泭銆�<\/p> \n

鍩轰簬DESTINY-PanTumor02銆丏ESTINY-Lung01鍜孌ESTINY-CRC02鐮旂┒鐨勭枟鏁堢粨鏋滐紝寰锋洸濡ョ彔鍗曟姉锛�5.4 mg\/kg锛夊湪缇庡浗鑾锋壒鐢ㄤ簬娌荤枟鏃㈠線鎺ュ彈杩囧叏韬不鐤椾笖鏃犳弧鎰忔浛浠ｆ不鐤楅€夋嫨鐨勪笉鍙垏闄ゆ垨杞Щ鎬ER2闃虫€э紙IHC 3+锛夊疄浣撶槫鎴愪汉鎮ｈ€呫€傚湪纭瘉鎬х爺绌朵腑鐨勪复搴婅幏鐩婂緱鍒伴獙璇佸拰纭畾鍚庯紝灏嗘湁鏈涙敮鎸佹湰閫傚簲鐥囧湪缇庡浗鐨勫畬鍏ㄦ壒鍑嗐€�<\/p> \n

鍏充簬绗竴涓夊叡鑲跨槫绠＄嚎<\/b><\/p> \n

绗竴涓夊叡鑲跨槫涓氬姟浠ョ涓€涓夊叡鍘熺爺鐙垱鐨凞Xd鎶椾綋鑽墿鍋惰仈鐗╋紙ADC锛夋妧鏈负渚濇墭锛岀洰鍓嶇涓€涓夊叡DXd ADC浜у搧缁勫悎涓昏鏈夊叚娆惧浜庝复搴婂紑鍙戦樁娈电殑ADC鑽墿锛屾兜鐩栧绉嶇檶鐥囩被鍨嬨€傚痉鏇插Ε鐝犲崟鎶楋紙HER2闈跺悜ADC锛夊拰 datopotamab deruxtecan锛圱ROP2 闈跺悜ADC锛夌洰鍓嶆鐢辩涓€涓夊叡涓庨樋鏂埄搴峰叡鍚屽紑鍙戝苟鍦ㄥ叏鐞冭寖鍥村唴鍟嗕笟鍖栥€侾atritumab deruxtecan锛圚ER3-DXd锛孒ER3闈跺悜ADC锛夛紝ifinatamab deruxtecan锛圛-DXd锛孊7-H3 鐨� ADC锛夛紝raludotatug deruxtecan锛圧-DXd锛孋DH6 闈跺悜ADC锛夋鐢辩涓€涓夊叡涓庨粯娌欎笢鍏卞悓寮€鍙戝苟鍦ㄥ叏鐞冭寖鍥村唴鍟嗕笟鍖栬繖涓夋鑽墿銆傜涓€涓夊叡姝ｇ嫭绔嬪紑鍙� DS-3939锛圱A-MUC1闈跺悜ADC锛夈€傚痉杈惧崥濡ュ崟鎶椼€乮finatamab deruxtecan銆乸atritumab deruxtecan銆乺aludotatug deruxtecan鍜孌S-3939鍧囦负鍦ㄧ爺鑽墿锛屽皻鏈湪浠讳綍鍥藉\/鍦板尯鑾锋壒鐢ㄤ簬浠讳綍閫傚簲鐥囥€傚皻鏈畬鍏ㄧ‘瀹氬畨鍏ㄦ€у拰鐤楁晥銆�<\/p> \n

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