(function(){
var content_array=["鍏充簬鍕冩灄鏍兼鏍肩堪<\/b><\/p> \n
鍕冩灄鏍兼鏍肩堪鑷村姏浜庣爺绌剁獊鐮存€х枟娉曪紝鏃ㄥ湪鍙橀潻鐢熷懡锛屽畧鎶や笘涓栦唬浠ｇ殑鍋ュ悍銆備綔涓轰竴瀹剁爺鍙戦┍鍔ㄧ殑鍏ㄧ悆棰嗗厛鐢熺墿鍒惰嵂浼佷笟锛屽叕鍙稿湪鍖荤枟闇€姹傞珮搴︽湭寰楀埌婊¤冻鐨勯鍩熼€氳繃鍒涙柊灞曠幇浠峰€笺€傚媰鏋楁牸娈锋牸缈拌嚜1885骞存垚绔嬩互鏉ヤ竴鐩存槸涓€瀹剁嫭绔嬬殑瀹舵棌浼佷笟锛屽缁堢潃鐪奸暱杩滀笌鍙寔缁彂灞曘€傚湪浜虹敤鑽搧銆佸姩鐗╀繚鍋ヤ袱澶т笟鍔￠鍩燂紝鍏ㄧ悆鏈夎秴杩�5.3涓囧悕鍛樺伐鏈嶅姟閫�130涓湴鍖恒€傛洿澶氳鎯咃紝璇疯闂細www.boehringer-ingelheim.com<\/a><\/p> \n
鍏充簬涓浗鐢熺墿鍒惰嵂<\/b><\/p> \n
涓浗鐢熺墿鍒惰嵂鏈夐檺鍏徃鍙婇檮灞炲叕鍙告槸涓浗棰嗗厛鐨勫垱鏂扮爺绌跺拰鐮斿彂椹卞姩鍨嬪尰鑽泦鍥紝涓氬姟瑕嗙洊鍖昏嵂鐮斿彂骞冲彴銆佹櫤鑳藉寲鐢熶骇鍜屽己澶ч攢鍞綋绯诲叏浜т笟閾俱€備骇鍝佸寘鎷绉嶇敓鐗╄嵂鍜屽寲瀛﹁嵂锛屽湪鑲跨槫銆佽倽鐥呫€佸懠鍚哥郴缁熴€佸绉慭/闀囩棝鍥涘ぇ娌荤枟棰嗗煙澶勪簬浼樺娍鍦颁綅銆傚叕鍙镐簬2000骞村湪棣欐腐鑱斾氦鎵€涓婂競锛�2013骞村叆閫塎SCI鍏ㄧ悆鏍囧噯鎸囨暟涔嬩腑鍥芥寚鏁版垚鍒嗚偂锛�2018骞村叆閫夋亽鐢熸寚鏁版垚鍒嗚偂锛�2019骞村叆閫夋亽鐢熶腑鍥戒紒涓氭寚鏁版垚鍒嗚偂锛�2020骞村叆閫夋亽鐢熸勃娣辨腐閫氱敓鐗╃鎶€50鎸囨暟鎴愬垎鑲°€佹亽鐢熶腑鍥斤紙棣欐腐涓婂競锛�25鎸囨暟銆備腑鍥界敓鐗╁埗鑽繛缁洓骞磋崳鐧荤編鍥芥潈濞佹潅蹇椼€婂埗鑽粡鐞嗕汉銆嬪彂甯冪殑"鍏ㄧ悆鍒惰嵂浼佷笟TOP50",杩炵画涓夊勾鑾疯瘎銆婄甯冩柉銆嬶紙浜氭床锛�"浜氬お鏈€浣冲叕鍙�50寮�"銆�<\/p> \n
鍏充簬brigimadlin<\/b><\/p> \n
Brigimadlin (BI 907828) 鏄竴绉嶉珮鏁堢殑鍙ｆ湇 MDM2-p53 鎷姉鍓傘€侭rigimadlin 鍙笌 MDM2 缁撳悎锛屾姂鍒� MDM2 鍜� p53 铔嬬櫧涔嬮棿鐨勭浉浜掍綔鐢ㄣ€傚畠鑳介樆姝� MDM2 鎶戝埗 p53锛屼粠鑰屾仮澶� p53 鐨勫姛鑳姐€俻53 鐨勭ǔ瀹氫細瀵艰嚧 TP53 闈跺熀鍥犵殑璇卞锛岃繘鑰屽鑷� TP53 閲庣敓鍨嬭偪鐦ょ粏鑳炵殑缁嗚優鍛ㄦ湡鍋滄粸鎴栧噵浜°€�<\/p> \n
鐩墠锛岄拡瀵筨rigimadlin鐨勫嚑椤逛复搴婅瘯楠屾鍦ㄨ繘琛屼腑锛屽寘鎷竴椤硅瘎浼癰rigimadlin瀵规瘮澶氭煍姣旀槦浣滀负鏅氭湡DDLPS鎮ｈ€呬竴绾挎不鐤楃殑II\/III鏈熻瘯楠岋紱涓€椤硅瘎浼癰rigimadlin娌荤枟鑳嗛亾鐧岋紙BTC锛夊拰鍏朵粬瀹炰綋鐦わ紙鑳拌吅鐧屻€佸翱璺笂鐨檶銆佽偤鐧岋級鎮ｈ€呯殑II鏈熻瘯楠岋紱涓€椤瑰brigimadlin涓庢斁鐤楄仈鍚堟不鐤楄兌璐ㄦ瘝缁嗚優鐦よ繘琛岃瘎浼扮殑 0\/Ia 鏈熻瘯楠屻€�<\/p> \n
缇庡浗椋熷搧鍜岃嵂鐗╃鐞嗗眬锛團DA锛夊凡缁忔巿浜� brigimadlin 娌荤枟鍘诲垎鍖栬剛鑲倝鐦わ紙DDLPS锛夌殑蹇€熼€氶亾璁ゅ畾锛屽拰娌荤枟 BTC 鐨勫鍎胯嵂璁ゅ畾銆�<\/p> \n
浜嗚В鏇村淇℃伅锛岃璁块棶 https:\/\/pro.boehringer-ingelheim.com\/inoncology\/our-pipeline\/mdm2-p53-antagonist<\/a>銆�<\/p> \n
鍏充簬<\/b>zongertinib<\/b><\/p> \n
Zongertinib锛圔I 1810631锛夋槸涓€绉嶉€夋嫨鎬� HER2 鎶戝埗鍓傦紝瀹冭兘涓庨噹鐢熷瀷鍜岀獊鍙樺瀷 HER2 鍙椾綋锛堝寘鎷惡甯﹀鏄惧瓙20 绐佸彉锛夌殑閰皑閰告縺閰剁粨鏋勫煙 (TKD) 鍏变环缁撳悎銆侶ER2 TKI 閫夋嫨鎬х殑鎻愰珮鍙兘浼氬甫鏉ユ洿濂界殑鑰愬彈鎬у拰鐤楁晥銆�<\/p> \n
鐩墠锛孼ongertinib鍗曡嵂娌荤枟姝ｅ湪鏅氭湡鎴栬浆绉绘€у疄浣撶槫鎮ｈ€呬腑杩涜鍏ㄧ悆 I 鏈熻瘯楠屻€備竴椤� Ia鏈熺爺绌跺叧浜庢帰绱ongertinib鍦ㄦ惡甯ER2鍙樺紓鐨勫疄浣撶槫鎮ｈ€呬腑鐨勮嵂浠ｅ姩鍔涘鍜屽畨鍏ㄦ€ц瘉姝ｅ湪杩涜銆備竴椤�1b鏈熺爺绌舵鍦ㄨ瘎浼皕ongertinib鍦℉ER2绐佸彉鐨凬SCLC鎮ｈ€呬腑鐨勫畨鍏ㄦ€у拰鐤楁晥鎬с€�<\/p> \n
缇庡浗 FDA 宸茬粡鎺堜簣 zongertinib 蹇€熼€氶亾璁ゅ畾锛屼綔涓轰竴绉嶇爺绌舵€у彛鏈嶆不鐤楄嵂鐗╋紝鐢ㄤ簬娌荤枟HER2 绐佸彉涓斿湪閾傜被鑽墿娌荤枟鏈熼棿鎴栦箣鍚庣柧鐥呰繘灞曠殑NSCLC鎮ｈ€呫€�<\/p> \n
鍏充簬<\/b>DLL3\/CD3 T<\/b>缁嗚優琛旀帴鍣�<\/b><\/p> \n
BI 764532 鏄竴绉� Delta 鏍峰吀鍨� Notch 閰嶄綋 3\/鍒嗗寲绨� 3 (DLL3\/CD3) T缁嗚優琛旀帴鍣ㄣ€� DLL3\/CD3 T缁嗚優琛旀帴鍣ㄤ綔涓烘ˉ姊侊紝鑳藉皢缁嗚優婧惰ВT缁嗚優閫夋嫨鎬у湴瀵煎悜琛ㄨ揪DLL3鐨勮偪鐦ゃ€�<\/p> \n
BI 764532 姝ｅ浜嶪 鏈熷拰 II 鏈熺爺绌朵腑锛屽 SCLC 鍜� NECs 鎮ｈ€呰繘琛岃瘎浼般€備复搴婂墠鐮旂┒缁撴灉琛ㄦ槑锛孌LL3\/CD3 鍗曡嵂鍙互鏈夋晥鎶戝埗 DLL3 闃虫€х殑SCLC寮傜绉绘妯″瀷鐨勭敓闀匡紝骞跺憟鍓傞噺渚濊禆鎬у拰鏃堕棿渚濊禆鎬с€傚畠杩橀€氳繃灏� CD4 闃虫€缁嗚優鍜� CD8 闃虫€х粏鑳炴瘨鎬 缁嗚優鐨勮浆鍚� DLL3 闃虫€� SCLC 缁嗚優锛岃皟鑺傝偪鐦ょ粍缁囩殑鐐庣棁鐜锛岃€屼笉褰卞搷 DLL3 闃存€ч澏缁嗚優銆�<\/p> \n
BI 764532 琚編鍥� FDA 鎺堜簣蹇€熼€氶亾璁ゅ畾锛岀敤浜庢不鐤楄〃杈� DLL3 鐨勬櫄鏈熸垨杞Щ鎬ц偤澶х粏鑳炵缁忓唴鍒嗘硨鐧岋紙LCNEC-Lung锛夛紝杩欎簺鎮ｈ€呰嚦灏戞帴鍙楄繃涓€绉嶆棦寰€鍚搨娌荤枟骞跺嚭鐜扮柧鐥呰繘灞曘€侭I 764532 鍚屾椂琚巿浜堝揩閫熼€氶亾璁ゅ畾锛岀敤浜庢不鐤楀箍娉涙湡 SCLC (ES-SCLC)锛岃繖浜涙偅鑰呭湪鑷冲皯涓ょ鏃㈠線娌荤枟鏂规锛堝寘鎷搨绫诲寲鐤楋級鍚庡嚭鐜扮柧鐥呰繘灞曪紱浠ュ強娌荤枟鑲哄 NEC (EP-NEC)锛岃繖浜涙櫄鏈熸垨杞Щ鎬ф偅鑰呰嚦灏戞帴鍙楄繃涓€绉嶆棦寰€娌荤枟锛堝寘鎷搨绫诲寲鐤楋級鍚庣柧鐥呰繘灞曪紱姝ゅ锛孊I 764532杩樿鎺堜簣娌荤枟SCLC 鐨勫鍎胯嵂璁ゅ畾銆�<\/p> \n
浜嗚В鏇村淇℃伅锛岃璁块棶 https:\/\/pro.boehringer-ingelheim.com\/inoncology\/our-pipeline\/dll3-cd3-t-cell-engager<\/a>銆�<\/p> \n