鍏充簬<\/b>POETYK PSO<\/b>涓村簥鐮旂┒椤圭洰<\/b><\/p> \n
POETYK PSO鏄敤浠ヨ瘎浼伴€夋嫨鎬� TYK2 鎶戝埗鍓俤eucravacitinib鐤楁晥鍜屽畨鍏ㄦ€х殑涓村簥鐮旂┒椤圭洰銆備袱椤瑰叏鐞冨涓績銆侀殢鏈恒€佸弻鐩睮II鏈熺爺绌禤OETYK PSO-1锛圢CT03624127锛夊拰POETYK PSO-2锛圢CT03611751锛夋棬鍦ㄨ瘎浼癲eucravacitinib 锛�6 mg锛屾瘡鏃ヤ竴娆★級瀵规瘮瀹夋叞鍓傚拰闃挎櫘绫冲徃鐗癸紙30 mg锛屾瘡鏃ヤ袱娆★級鐢ㄤ簬娌荤枟涓噸搴︽枒鍧楃姸閾跺睉鐥呮偅鑰呯殑鐤楁晥鍜屽畨鍏ㄦ€с€傚叾涓璓OETYK PSO-1鍏卞叆缁�666鍚嶆偅鑰咃紝POETYK PSO-2鍏卞叆缁�1,020鍚嶆偅鑰呫€侾OETYK PSO-2杩樺寘鎷24鍛ㄥ悗鐨勯殢鏈烘挙鑽拰鍐嶆不鐤楅樁娈点€�<\/p> \n
POETYK PSO-1 鍜� POETYK PSO-2鐮旂┒鐨勫叡鍚屼富瑕佺爺绌剁粓鐐瑰潎涓猴細涓庡畨鎱板墏鐩告瘮锛屽湪绗�16鍛ㄨ揪鍒癙ASI 75锛堥摱灞戠梾闈㈢Н涓庝弗閲嶇▼搴︽寚鏁拌瘎鍒嗘敼鍠勮嚦灏�75%锛夊拰闈欐€佸尰鐢熸€讳綋璇勪及璇勫垎0鎴�1鍒嗭紙sPGA 0\/1锛岀毊鎹熸竻闄/鍩烘湰娓呴櫎锛夌殑鎮ｈ€呮瘮渚嬨€傚叧閿瑕佺爺绌剁粓鐐瑰寘鎷笌闃挎櫘绫冲徃鐗圭浉姣旓紝鍦ㄧ16鍛ㄨ揪鍒癙ASI 75銆丳ASI 90鍜宻PGA 0\/1鐨勬偅鑰呮瘮渚嬶紝浠ュ強璇勪及deucravacitinib 瀵规瘮瀹夋叞鍓傚拰闃挎櫘绫冲徃鐗圭殑鍏朵粬鎸囨爣銆�<\/p> \n
鍦ㄥ畬鎴愪负鏈� 52 鍛ㄧ殑 POETYK PSO-1 鍜� POETYK PSO-2 鐨勭爺绌跺悗锛屾偅鑰呭彲鍙傚姞 POETYK PSO闀挎湡鎵╁睍锛圠TE锛夎瘯楠岋紙NCT04036435锛夛紝浠ュ紑鏀炬爣绛惧舰寮忕户缁帴鍙梔eucravacitinib 锛�6 mg锛屾瘡鏃ヤ竴娆★級娌荤枟銆傦紙鎴嚦LTE璇曢獙2骞存暟鎹彂琛ㄦ椂锛夊叡璁� 1,221 鍚嶆偅鑰呭弬鍔犱簡LTE璇曢獙锛屽苟鎺ュ彈浜嗚嚦灏� 1 娆eucravacitinib 娌荤枟銆傜爺绌朵娇鐢ㄦ不鐤楀け璐ヨ鍒欙紙TFR锛夋彃琛ユ硶鏉ュ垎鏋愮枟鏁堬紝鍚屾椂浣跨敤鏀硅壇鏃犲簲绛旀彃琛ユ硶鍜屽疄闄呰瀵熸硶杩涜浜嗘晱鎰熸€у垎鏋愶紝杩欎簺鍒嗘瀽宸茬敤浜庡叾浠栬嵂鍓傜殑绫讳技鍒嗘瀽銆傞櫎浜� POETYK PSO-1銆丳OETYK PSO-2 鍜� POETYK PSO-LTE锛岀櫨鏃剁編鏂借吹瀹濈洰鍓嶈繕寮€灞曚簡鍙﹀涓ら」III鏈熺爺绌朵互璇勪及 deucravacitinib鐢ㄤ簬閾跺睉鐥呮不鐤楃殑鎯呭喌锛屽畠浠垎鍒槸POETYK PSO-3锛圢CT04167462锛夊拰 POETYK PSO-4锛圢CT03924427锛夈€�<\/p> \n
鍏充簬閾跺睉鐥�<\/b><\/p> \n
閾跺睉鐥呮槸涓€绉嶅父瑙佺殑鎱㈡€с€佺郴缁熸€у厤鐤粙瀵肩柧鐥咃紝涓ラ噸鎹熷鎮ｈ€呯殑韬綋鍋ュ悍銆佺敓娲昏川閲忓拰宸ヤ綔鏁堢巼銆備綔涓轰竴涓叏鐞冩€т弗閲嶉棶棰橈紝鍏ㄤ笘鐣岃嚦灏�1浜夸汉鍙楀埌鍚勭被閾跺睉鐥呯殑褰卞搷锛屽叾涓娲茬害鏈�1,400涓囦汉锛岀編鍥界害鏈�750 涓囦汉銆傝繎鍥涘垎涔嬩竴閾跺睉鐥呮偅鑰呯殑鐤剧梾涓ラ噸绋嬪害涓轰腑搴﹁嚦閲嶅害銆傞珮杈�90%鐨勯摱灞戠梾鎮ｈ€呬负瀵诲父鍨嬮摱灞戠梾鎴栨枒鍧楃姸閾跺睉鐥咃紝鍏剁壒寰佹槸鐣岄檺娓呮鐨勫渾褰㈡垨妞渾褰㈡枒鍧楋紝琛ㄩ潰閫氬父瑕嗘湁閾剁櫧鑹查碁灞戙€傚敖绠＄洰鍓嶅凡鏈夋湁鏁堢殑绯荤粺鎬ф不鐤楁柟妗堬紝浣嗚澶氫腑閲嶅害閾跺睉鐥呮偅鑰呬粛鏈緱鍒板厖鍒嗘不鐤楃敋鑷虫湭缁忔不鐤楋紝涓旂洰鍓嶇殑娌荤枟鏂规骞舵棤娉曟弧瓒冲叾娌荤枟闇€姹傘€傞摱灞戠梾褰卞搷鎮ｈ€呯殑鎯呯华鍋ュ悍锛屽甫鏉ユ棩甯镐笌鑱屽満鐨勭ぞ浜ゅ帇鍔涳紝閫犳垚鐢熸椿璐ㄩ噺涓嬮檷銆傛澶栵紝閾跺睉鐥呰繕涓庡绉嶅彲鑳藉奖鍝嶆偅鑰呭仴搴风殑鍚堝苟鐥囩浉鍏筹紝鍖呮嫭閾跺睉鐥呭叧鑺傜値銆佸績琛€绠＄柧鐥呫€佷唬璋㈢患鍚堝緛銆佽偉鑳栥€佺硸灏跨梾銆佺値鐥囨€ц偁鐥呭拰鎶戦儊鐥囥€�<\/p> \n
鍏充簬<\/b>deucravacitinib<\/b><\/p> \n
Deucravacitinib鏄竴绉嶅叿鏈夌嫭鐗逛綔鐢ㄦ満鍒剁殑鍙ｆ湇銆侀€夋嫨鎬ч叒姘ㄩ吀婵€閰� 2锛圱YK2锛夊彉鏋勬姂鍒跺墏锛屼篃鏄竴绫绘柊鐨勫皬鍒嗗瓙鑽墿浠ｈ〃銆傚畠鏄涓鍦ㄨ繘琛屽绉嶅厤鐤粙瀵肩柧鐥呬复搴婄爺绌剁殑閫夋嫨鎬YK2鎶戝埗鍓傘€傜櫨鏃剁編鏂借吹瀹濈殑绉戝瀹朵滑璁捐deucravacitinib 鏉ラ€夋嫨鎬у湴闈跺悜 TYK2锛屼粠鑰屾姂鍒禝L-23銆両L-12 鍜孖 鍨嬪共鎵扮礌锛圛FN锛夌殑淇″彿浼犲锛岃€岃繖浜涚粏鑳炲洜瀛愰兘鏄弬涓庡绉嶅厤鐤粙瀵肩柧鐥呭彂鐥呮満鍒剁殑鍏抽敭缁嗚優鍥犲瓙銆侱eucravacitinib 閫氳繃涓� TYK2 鐨勮皟鑺傜粨鏋勫煙缁撳悎瀹炵幇楂樺害閫夋嫨鎬э紝淇冩垚瀵筎YK2 鍙婂叾涓嬫父鍔熻兘鐨勫彉鏋勬姂鍒躲€傚湪鐢熺悊娴撳害鑼冨洿鍐咃紝deucravacitinib 閫夋嫨鎬у湴鎶戝埗 TYK2銆傚湪娌荤枟鍓傞噺涓嬶紝deucravacitinib 涓嶄細鎶戝埗JAK1銆丣AK2 鎴� JAK3銆�<\/p> \n
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