鍏充簬<\/u><\/b>CheckMate-743<\/u><\/b><\/p> \n
CheckMate -743鏄竴椤瑰紑鏀炬爣绛俱€佸涓績銆侀殢鏈篒II鏈熶复搴婄爺绌讹紝鏃ㄥ湪璇勪及娆х媱娌冭仈鍚堥€告矁瀵规瘮鏍囧噯鍖栫枟锛堝煿缇庢洸濉炶仈鍚堥『閾傛垨鍗￠搨锛夌敤浜庢棦寰€鏈粡娌荤枟鐨勪笉鍙垏闄ょ殑鎭舵€ц兏鑶滈棿鐨槫锛圡PM锛夋偅鑰咃紙n=605锛夌殑娌荤枟鏁堟灉銆傚湪璇ョ爺绌朵腑锛�303渚嬫偅鑰呴殢鏈烘帴鍙楁鐙勬矁锛�3mg\/kg锛屾瘡2鍛ㄤ竴娆★級鑱斿悎閫告矁锛�1mg\/kg锛屾瘡6鍛ㄤ竴娆★級娌荤枟锛屾寔缁不鐤楃洿鑷冲嚭鐜扮柧鐥呰繘灞曟垨涓嶅彲鑰愬彈鐨勬瘨鎬э紝鏈€闀挎不鐤楁椂闂翠负24涓湀銆�302渚嬫偅鑰呴殢鏈烘帴鍙楅『閾傦紙75mg\/m2<\/sup>锛夋垨鍗￠搨锛圓UC 5锛夎仈鍚堝煿缇庢洸濉烇紙500mg\/m2<\/sup>锛夋不鐤楋紝姣�3鍛ㄤ竴娆★紝鎸佺画6涓懆鏈燂紝鎴栧嚭鐜扮柧鐥呰繘灞曟垨涓嶅彲鑰愬彈鐨勬瘨鎬с€傝瘯楠岀殑涓昏缁堢偣涓烘墍鏈夐殢鏈烘偅鑰呯殑鎬荤敓瀛樻湡锛圤S锛夛紝鍏朵粬鐤楁晥缁撳眬鎸囨爣鍖呮嫭鏃犺繘灞曠敓瀛樻湡锛圥FS锛夈€佸瑙傜紦瑙ｇ巼锛圤RR锛夊拰鎸佺画缂撹В鏃堕棿锛圖OR锛夛紝鐢辩洸鎬佺嫭绔嬩腑蹇冨鏌ュ鍛樹細锛圔ICR锛夋牴鎹敼鑹殑RECIST鏍囧噯杩涜璇勪及銆傛帰绱㈡€х粓鐐瑰寘鎷畨鍏ㄦ€с€佽嵂浠ｅ姩鍔涘锛屽厤鐤師鎬у拰鎮ｈ€呮姤鍛婄殑娌荤枟缁撳眬銆�<\/p> \n
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