鍏充簬<\/b> FasT CAR-19<\/b><\/p> \n

FasT CAR-19锛屾垨 GC007F锛屾槸涓€绉嶉澏鍚� CD19 鐨� CAR-T 缁嗚優娌荤枟锛岄€傜敤浜庡鍙慭/闅炬不鎬� B-ALL 鐨勯潚灏戝勾鍜屾垚骞存偅鑰咃紝浠ュ強闈為湇濂囬噾娣嬪反鐦わ紙NHL锛夋偅鑰呫€備簶鍠滅敓鐗╃殑涓撳埄FasTCAR^{TM<\/sup>鎶€鏈皢 GC007F鐨勫埗澶囪繃绋嬬缉鍑忚嚦24灏忔椂锛屽ぇ澶у湴闄嶄綆浜嗗叾鎴愭湰锛涜繖绉嶈〃鍨嬫洿骞磋交涓旀洿灏戣€楃鐨凾缁嗚優琛ㄧ幇鍑烘洿寮虹殑澧炴畺鑳藉姏銆佹潃浼ゆ晥鍔涳紝鍜屾洿澶ц寖鍥撮楂撲互鍙婅劸鑴忕殑杩佺Щ鑳藉姏锛屼娇寰� GC007F 鏈夋湜鎴愪负澶嶅彂鎴栭毦娌绘€� B-ALL 鍙奛HL鐨勬渶浣矯AR-T娌荤枟鏂规銆�<\/p> \n}

鍏充簬<\/b> Dual CAR-19-22<\/b><\/p> \n

Dual CAR-19-22锛屾垨GC022锛屾槸涓€绉嶇爺绌舵€AR-T缁嗚優鐤楁硶锛岄€氳繃鍦ㄥ悓涓€涓猅缁嗚優涓婅〃杈惧弻鎶椾綋闈跺悜CD19鍜孋D22鎶楀師锛屾不鐤桟D19闃虫€ф垨\/鍜孋D22闃虫€х殑澶嶅彂\/闅炬不B-ALL鎮ｈ€呫€傛鐤楁硶鍏锋湁鍓傞噺渚濊禆鐨勯珮CR鐜囥€佷綆姣掓€э紝鍏ョ粍鍙楄瘯鑰呬腑鍖呮嫭鏃㈠線鎺ュ彈杩嘋D19 CAR-T娌荤枟鏃犳晥鐨勬偅鑰呫€�<\/p> \n

鍏充簬<\/b> Dual CAR-BCMA-19<\/b><\/p> \n

Dual CAR-BCMA-19锛屾垨GC012锛屾槸涓€绉嶇爺绌舵€AR-T缁嗚優鐤楁硶锛岄€氳繃鍦ㄥ悓涓€涓猅缁嗚優涓婅〃杈惧弻鎶椾綋闈跺悜 BCMA 鍜� CD19鎶楀師锛屾不鐤� BCMA闃虫€ф垨\/鍜孋D19闃虫€х殑澶嶅彂\/闅炬不MM鎮ｈ€呫€傚厛鍓嶇殑鐮旂┒琛ㄦ槑锛孋D19鍙湪楠ㄩ珦鐦ょ缁嗚優涓婅〃杈撅紝鑰� BCMA 鏄竴涓粡杩囧厖鍒嗛獙璇佺殑 MM 闈舵爣銆�<\/p> \n

鍏充簬<\/b> Donor CAR-19<\/b><\/p> \n

Donor CAR-19锛屾垨GC007G锛屾槸鍒╃敤鎮ｈ€呭共缁嗚優绉绘渚涗綋鐨勬穻宸寸粏鑳炵敓浜х殑涓€绉嶇爺绌舵€ч澏鍚慍D19鐨凜AR-T缁嗚優鐤楁硶銆傛湰鐮旂┒鐨勭洰鐨勬槸杩涗竴姝ョ爺绌讹紝鏇村ソ鍦颁簡瑙ｄ緵浣撴潵婧愮殑CAR-T缁嗚優娌荤枟澶嶅彂\/闅炬不B-ALL鎮ｈ€呯殑瀹夊叏鎬т笌鏈夋晥鎬с€�<\/p> \n

鍏充簬<\/b> B-ALL<\/b><\/p> \n

B-ALL 鏄€ユ€ф穻宸寸粏鑳炵櫧琛€鐥呯殑涓€涓簹鍨嬶紝鏄� 2-5 宀佸効绔ュ拰 50 宀佷互涓婃垚浜轰腑鏈€甯歌鐨勭檶鐥囦箣涓€^{[1]<\/sup><\/sup>銆�2015 骞达紝鍏ㄧ悆鍏辨湁 87.6 涓囦汉鎮ｆ湁 ALL锛屾湁 11 涓囦汉鍥犺€屾浜�[2]<\/sup><\/sup>銆傝繖涓€鐤剧梾涔熸槸鍎跨鏈€甯歌鐨勭檶鐥囪鍥犲拰鐧岀棁姝讳骸璇卞洜銆侫LL 鐨勫父瑙勭枟娉曚负鍏堥€氳繃鍖栫枟缂撹В锛岃€屽悗鏁板勾闂村潎闇€鎺ュ彈杩涗竴姝ュ寲鐤椼€�<\/p> \n}

鍏充簬 <\/b>MM<\/b><\/p> \n

楠ㄩ珦鐦ょ殑璧峰洜婧愪簬娴嗙粏鑳炲紓甯革紝寮傚父娴嗙粏鑳炲垎鍖栧悗鍙嚜鎴戝鍒讹紝姝ょ被寮傚父娴嗙粏鑳炲嵆绉颁负楠ㄩ珦鐦ょ粏鑳炪€傞殢鐫€鏃堕棿鎺ㄧЩ锛岄楂撶槫缁嗚優浼氳仛闆嗗湪楠ㄩ珦涓紝浠庤€屾崯浼ら楠肩殑瀹炰綋缁撴瀯銆傚綋楠ㄩ珦鐦ょ粏鑳炶仛闆嗕簬澶氬楠ㄩ鏃讹紝鍒欑О涓衡€滃鍙戞€ч楂撶槫鈥濄€傛鐤剧梾涔熷彲鑳戒細鎹熷鍏朵粬缁勭粐鍜屽櫒瀹橈紝姣斿鑲捐剰銆傞楂撶槫缁嗚優鍙互浜х敓鎶椾綋锛岀О涓� M 铔嬬櫧鍜屽叾浠栬泲鐧姐€傛绫昏泲鐧借川浼氳仛闆嗕簬琛€娑层€佸翱娑插強鑴忓櫒涓�^{[3]<\/sup>銆�<\/p> \n}

鍏充簬 浜樺枩鐢熺墿<\/b><\/p> \n

浜樺枩鐢熺墿绉戞妧鏈夐檺鍏徃锛堢畝绉扳€滀簶鍠滅敓鐗┾€濓級鏄竴瀹朵复搴婂紑鍙戦樁娈电殑鐢熺墿鎶€鏈叕鍙搞€備簶鍠滅敓鐗╁姏姹傝В鍐矯AR-T琛屼笟闈复鐨勬寫鎴橈紝濡傞珮鐢熶骇鎴愭湰銆佸埗閫犺繃绋嬫极闀裤€佺己涔忕幇鎴愮殑浜у搧銆佷互鍙婂瀹炰綋鑲跨槫鏃犳晥绛夈€傚湪涓栫晫绾х瀛﹀鍥㈤槦鐨勯瀵间笅锛屼簶鍠滅敓鐗╂鑷村姏浜庡紑鍙� FasTCAR^{TM<\/sup>銆乀ruUCARTM<\/sup>锛堢幇璐AR-T浜у搧锛夈€丏ual CAR 鍜孍nhanced CAR-T缁嗚優鐤楁硶锛岀敤浜庢不鐤楃櫧琛€鐥呫€佹穻宸寸槫銆侀楂撶槫鍜屽疄浣撶槫銆�<\/p> \n}

^{[1]<\/sup><\/sup> https:\/\/www.cancer.org\/cancer\/acute-lymphocytic-leukemia\/about\/key-statistics.html<\/a>
[2]<\/sup><\/sup> https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5055577\/<\/a>
[3]<\/sup> <\/sup>https:\/\/seer.cancer.gov\/statfacts\/html\/mulmy.html<\/a> <\/p> \n}

鑱旂郴鏂瑰紡锛�<\/b><\/p> \n