1. <\/strong>鍏充簬<\/strong>Fycompa<\/strong>锛堝悺浠戝笗濂堬級<\/strong><\/p> \n

Fycompa鏄敱鍗潗鐙鐮斿彂鐨勪竴绉嶆柊鍨嬫姉鐧棲鑽墿銆傜櫕鐥彂浣滄満鍒朵箣涓€鏄敱绁炵粡閫掕川璋锋皑閰镐粙瀵肩殑銆傝鑽槸涓€绉嶉珮閫夋嫨鎬с€侀潪绔炰簤鎬х殑 AMPA 鍨嬪彈浣撴嫯鎶楀墏锛屽彲閫氳繃闈跺悜绐佽Е鍚庣粏鑳炶啘涓夾MPA鍙椾綋澶勭殑璋锋皑閰告椿鎬э紝鍑忓皯涓庣櫕鐥彂浣滅浉鍏崇殑绁炵粡鍏冪殑杩囧害鍏村銆侳ycompa鐨勭墖鍓傝宸插湪鏃ユ湰涓婂競閿€鍞紝姣忔棩涓€娆★紝鐫″墠鍙ｆ湇銆傛澶栵紝璇ヨ嵂鐨勫彛鏈嶆偓娴埗鍓傚凡鑾峰噯鍦ㄧ編鍥戒笂甯傞攢鍞€�<\/p> \n

鐩墠锛孎ycompa宸插湪娆ф床鍜屼簹娲茶秴杩�55涓浗瀹跺拰鍦板尯锛堝寘鎷編鍥藉拰鏃ユ湰锛夎幏寰楁壒鍑嗭紝鐢ㄤ簬杈呭姪娌荤枟12宀佸強浠ヤ笂鐧棲鎮ｈ€呯殑閮ㄥ垎鎬у彂浣滐紙浼存垨涓嶄即缁у彂鍏ㄩ潰鎬х櫕鐥彂浣滐級銆傚崼鏉愪篃鍦ㄤ腑鍥芥彁浜や簡灏咶ycompa鐢ㄤ簬杈呭姪娌荤枟鐧棲閮ㄥ垎鎬у彂浣滅殑鐢宠锛屼笖宸茶鎸囧畾浼樺厛瀹℃煡銆傛澶栵紝Fycompa宸插湪娆ф床鍜屼簹娲茬殑50澶氫釜鍥藉锛堝寘鎷編鍥藉拰鏃ユ湰锛夎幏寰楁壒鍑嗭紝鐢ㄤ簬杈呭姪娌荤枟12宀佸強浠ヤ笂鐧棲鎮ｈ€呯殑鍘熷彂鎬у叏闈㈡€у己鐩� - 闃垫寷銆傚湪缇庡浗锛孎ycompa宸茶幏鍑嗙敤浜�4宀佸強浠ヤ笂鐧棲鎮ｈ€呯殑閮ㄥ垎鎬у彂浣滐紙浼存垨涓嶄即缁у彂鎬у叏闈㈡€х櫕鐥彂浣滐級鐨勫崟鑽不鐤椼€�<\/p> \n

杩勪粖涓烘锛孎ycompa宸叉不鐤楄繃鍏ㄤ笘鐣岃秴杩�200,000鍚嶆偅鑰呯殑鎵€鏈夌櫕鐥€傚簲鐥囥€�<\/p> \n

姝ゅ锛屽崼鏉愭鍦ㄥ叏鐞冭寖鍥村唴杩涜涓€椤笽II鏈熶复搴婄爺绌讹紙338鐮旂┒锛夛紝鎰忓湪灏嗚鑽敤浜庢不鐤椾笌LG锛圠ennox-Gastaut锛夌患鍚堝緛鐩稿叧鐨勭櫕鐥彂浣溿€�<\/p> \n

\n \n \n \n \n \n \n \n \n \n \n

鐮旂┒棰樼洰     <\/span><\/p> <\/td> \n

涓€椤规棤瀵圭収缁勩€佸紑鏀炬€х爺绌讹紝鐢ㄤ簬楠岃瘉鍚′粦甯曞瀵规湭缁忔不鐤楃殑鐧棲鎮ｈ€呯殑閮ㄥ垎鎬у彂浣滐紙鍖呮嫭缁у彂鎬у叏闈㈡€х櫕鐥彂浣滐級杩涜鍗曡嵂娌荤枟鐨勭枟鏁堝拰瀹夊叏鎬�<\/span><\/p> <\/td> \n <\/tr> \n

鐮旂┒浜虹兢            <\/span><\/p> <\/td> \n

骞撮緞涓�12宀佽嚦74宀併€佹湭鎺ュ彈杩囨不鐤楃殑鐧棲閮ㄥ垎鎬у彂浣滀笖浼存湁鎴栦笉浼存湁缁у彂鎬у叏闈㈢櫕鐥彂浣滅殑鎮ｈ€�<\/span><\/p> <\/td> \n <\/tr> \n

娌荤枟鏂规硶                    <\/span><\/p> <\/td> \n

鍙ｆ湇鍚′粦甯曞鐗囧墏4姣厠锛堢櫕鐥彂浣滄椂鍙淮瀹氳嚦8姣厠锛夛紝姣忔棩涓€娆★紝鐫″墠鏈嶇敤<\/span><\/p> <\/td> \n <\/tr> \n

娌荤枟鎸佺画鏃堕棿               <\/span><\/p> <\/td> \n

娌荤枟闃舵锛堟淮瀹氭湡锛�6鍛紝宸╁浐鏈燂細26鍛紙濡傛灉浠�4姣厠婊村畾鑷�8姣厠锛屾淮瀹氭湡涓�4鍛紝娌荤枟鏈熶负26鍛級锛�<\/span><\/p> <\/td> \n <\/tr> \n

寤堕暱鏈�<\/span><\/p> <\/td> \n <\/tr> \n

鐮旂┒鍦扮偣              <\/span><\/p> <\/td> \n

鏃ユ湰銆侀煩鍥�<\/span><\/p> <\/td> \n <\/tr> \n

涓昏缁堢偣                    <\/span><\/p> <\/td> \n

鎮ｆ湁鐧棲閮ㄥ垎鎬у彂浣滅殑鍙楄瘯鑰呭湪26鍛ㄧ殑缁存寔鏈熷唴鐨勬棤鐧棲鍙戜綔鐜�<\/span><\/p> <\/td> \n <\/tr> \n

缁撴灉                    <\/span><\/p> <\/td> \n

89鍚嶆偅鑰呮帴鍙椾簡Fycompa鍗曡嵂娌荤枟锛屽叾涓�73鍚嶆湇鐢�4 mg Fycompa鐨勬偅鑰呭湪娌荤枟鏈熼棿鏃犵櫕鐥彂浣滅殑姣斾緥瓒呰繃浜嗙枟鏁堟爣鍑�*锛屼笖杈惧埌浜嗕富瑕佺粓鐐广€傛澶栵紝涓湡缁撴灉琛ㄦ槑锛�4 mg鍜�8 mg鎮ｈ€呯殑鎬讳綋鎯呭喌涔熻秴杩囦簡鐤楁晥鏍囧噯銆傜爺绌�342涓瀵熷埌鐨勬渶甯歌鐨勪笉鑹弽搴旓紙鍙戠敓鐜囦负10锛呮垨鏇撮珮锛夋湁澶存檿銆佸棞鐫°€侀蓟鍜界値鍜屽ご鐥涳紝杩欎笌杩勪粖涓烘Fycompa鍙戝竷鐨勫畨鍏ㄦ€ц祫鏂欎竴鑷淬€�<\/span><\/p> <\/td> \n <\/tr> \n <\/tbody> \n <\/table> \n<\/div> \n
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*鏈爺绌跺寘鎷�73鍚嶆偅鑰咃紝鐤楁晥璇勪及鏍囧噯瑕佹眰鏈�52.1锛呮垨鏇撮珮姣斾緥鐨勬偅鑰呭疄鐜版棤鐧棲鍙戜綔銆傝繖涓€鏁板瓧鑰冭檻浜嗗叾浠栨姉鐧棲鑽墿鐨勫崟鑽不鐤楃爺绌剁粨鏋溿€�<\/span><\/p> <\/td> \n <\/tr> \n <\/tbody> \n <\/table> \n<\/div> \n
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3. 鍏充簬311鐮旂┒<\/span><\/p> \n
\n \n \n \n \n \n \n \n \n \n \n

鐮旂┒棰樼洰<\/span><\/p> <\/td> \n

涓€椤归潪鐩茬爺绌讹紝鐢ㄤ簬璇勪及鍚′粦甯曞鍙ｆ湇娣锋偓鍓傚湪鍎跨鍙楄瘯鑰呬腑杈呭姪娌荤枟鐢ㄥ叾浠栬嵂鐗╂棤娉曞畬鍏ㄦ帶鍒剁殑鐧棲閮ㄥ垎鎬у彂浣滄垨鍘熷彂鎬х櫕鐥叏闈㈡€у己鐩�-闃垫寷鎬у彂浣滅殑瀹夊叏鎬с€佽€愬彈鎬у拰鏆撮湶 - 鏁堣兘鍏崇郴銆�<\/span><\/p> <\/td> \n <\/tr> \n

鐮旂┒浜虹兢  <\/span><\/p> <\/td> \n

180鍚嶅勾榫勫湪4鑷�12宀侊紝鐢ㄥ叾浠栬嵂鐗╂棤娉曞畬鍏ㄦ帶鍒剁殑鐧棲閮ㄥ垎鎬у彂浣滄垨鍘熷彂鎬х櫕鐥叏闈㈠己鐩�-闃垫寷鎬у彂浣滅殑鎮ｈ€呫€�<\/span><\/p> <\/td> \n <\/tr> \n

娌荤枟鏂规硶<\/span><\/p> <\/td> \n

姣忔棩鍙ｆ湇鍚′粦甯曞 2-16 mg锛岀潯鍓嶆湇鐢ㄣ€�<\/span><\/p> <\/td> \n <\/tr> \n

娌荤枟鎸佺画鏃堕棿  <\/span><\/p> <\/td> \n

娌荤枟闃舵锛堟淮瀹氭湡锛氭渶闀�11鍛紝宸╁浐鏈燂細鏈€闀�12鍛級<\/span><\/p> <\/td> \n <\/tr> \n

寤堕暱鏈�<\/span><\/p> <\/td> \n <\/tr> \n

鐮旂┒鍦扮偣  <\/span><\/p> <\/td> \n

鍏ㄧ悆锛堢編鍥姐€佹娲层€佹棩鏈€佷簹娲诧級<\/span><\/p> <\/td> \n <\/tr> \n

涓昏缁堢偣       <\/span><\/p> <\/td> \n

瀹夊叏鎬у拰鑰愬彈鎬�<\/span><\/p> <\/td> \n <\/tr> \n

缁撴灉<\/span><\/p> <\/td> \n

鎺ュ彈Fycompa娌荤枟鐨�180鍚嶆偅鑰呯殑鐤楁晥涓�12宀佸強浠ヤ笂鎮ｈ€呯浉浼笺€傛湰鐮旂┒涓瀵熷埌鐨勬渶甯歌鐨勪笉鑹弽搴旓紙鍙戠敓鐜囦负10锛呮垨鏇撮珮锛夋湁鍡滅潯銆侀蓟鍜界値銆佸彂鐑€佸憰鍚愩€佸ご鏅曘€佹祦鎰熷拰鐑﹁簛锛岃繖涓庤縿浠婁负姝ycompa鐨勫畨鍏ㄦ€ц祫鏂欎竴鑷淬€�<\/span><\/p> <\/td> \n <\/tr> \n <\/tbody> \n <\/table> \n<\/div> \n
4. 鍏充簬Epilepsy<\/p> \n
缇庡浗澶х害鏈�340涓囩櫕鐥偅鑰咃紝鏃ユ湰绾︽湁100涓囷紝娆ф床绾︽湁600涓囷紝涓浗绾︽湁900涓囷紝鑰屽叏涓栫晫绾︽湁6000涓囨偅鑰呴ケ鍙楃櫕鐥殑鎶樼（銆傚ぇ绾�30%鐨勭櫕鐥偅鑰呬娇鐢ㄧ幇鏈夌殑鎶楃櫕鐥嵂鐗╀笉鑳芥帶鍒剁梾鎯呫€�^{[1] <\/span><\/sup>鎵€浠ワ紝鐧棲浠嶆槸涓€绉嶅尰鐤楅渶姹傛槑鏄炬湭婊¤冻鐨勭柧鐥呫€�<\/p> \n}
鐧棲涓€鑸寜鍙戜綔绫诲瀷鍒嗙被锛岀櫕鐥儴鍒嗘€у彂浣滅害鍗犵櫕鐥梾渚嬬殑60锛咃紝鐧棲鍏ㄩ潰鎬у彂浣滅害鍗�40锛呫€傚湪鐧棲閮ㄥ垎鎬у彂浣滀腑锛屽紓甯哥數骞叉壈鍙戠敓鍦ㄥぇ鑴戠殑鏌愬潡鍖哄煙锛屽苟鍙兘闅忓悗鎵╂暎鍒版暣涓剳閮紝鎴愪负鐧棲鍏ㄩ潰鎬у彂浣滐紙绉颁负缁у彂鍏ㄩ潰鎬х櫕鐥彂浣滐級銆傚湪鐧棲鍏ㄩ潰鎬у彂浣滀腑锛屽紓甯哥數骞叉壈鍙戠敓鍦ㄦ暣涓剳閮紝闅忓悗鍙兘鍑虹幇鎰忚瘑涓уけ鎴栧嚭鐜板叏韬棁鐘躲€�<\/p> \n
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[1] 鈥淭he Epilepsies and Seizures: Hope Through Research.What are the epilepsies?鈥漀ational Institute of Neurological Disorders and Stroke, accessed May 24, 2016, http:\/\/www.ninds.nih.gov\/disorders\/epilepsy\/detail_epilepsy.htm#230253109<\/a><\/span><\/p> <\/td> \n <\/tr> \n <\/tbody> \n <\/table> \n<\/div> \n
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